Atypical Hemolytic Uremic Syndrome Successfully Treated with Eculizumab / 대한내과학회지
Korean Journal of Medicine
; : 124-128, 2020.
Article
| WPRIM
| ID: wpr-836633
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WPRO
ABSTRACT
Atypical hemolytic uremic syndrome (aHUS) is a rare syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal injury, which results from uncontrolled complement activation. Delayed diagnosis and treatment of aHUS may result in end-stage renal disease (ESRD) and an associated dependence on dialysis. In extreme cases, it may cause death due to multi-organ failure. Eculizumab, a humanized monoclonal antibody against C5, inhibits the formation of the terminal membrane attack complex and is used to treat aHUS. Here, we report a 46-year-old male patient who suffered from aHUS relapse, despite prior treatment with repeated plasma exchange and hemodialysis. Eculizumab therapy improved his hematologic findings without use of hemodialysis.
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WPRIM
Journal:
Korean Journal of Medicine
Year:
2020
Type:
Article