Effect of sufentanil on calcium-activated potassium currents in rat abdominal aortic smooth muscle cells / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 1062-1064, 2010.
Article
in Zh
| WPRIM
| ID: wpr-840498
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ABSTRACT
Objective:
To investigate the influence of sufentanil on calcium-activated K+ channels (IKCa) in rat abdominal aortic smooth muscle cells, and to investigate its role in dilation of blood vessels.Methods:
Rat abdominal aortic smooth muscle cells (AASMCs) were freshly obtained by enzymatic digestion. Whole-cell voltage-clamp technique was used to assess the effect of sufentanil (1 × 10-8, 3 × 10-8, 1 × 10-7 mol/L) on IKCa.Results:
Sufentanil significantly increased the amplitude of IKc compared with the control group (P < 0.05 or P < 0.01). The effect of sufentanil was reversible and in a concentration-dependent manner.Conclusion:
Sufentanil can promote the activation of KCa channel in rat AASMCs, which might be related to the vasodilatory effect of sufentanil observed in clinical practice.
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Index:
WPRIM
Language:
Zh
Journal:
Academic Journal of Second Military Medical University
Year:
2010
Type:
Article