Influence of sulfonylureas on cardiovascular system: Progress in basic research and clinical research / 第二军医大学学报

ABSTRACT

Previous studies have showed that sulfonylureas possess a bidirectional effect on cardiovascular system: they can raise the coronary artery tone, aggravate ischemic injury to the cardiovascular tissues, and accelerate cardiac hypertrophy through closing cardiovascular ATP-sensitive K+ channels; meanwhile, they can also regulate glucolipid metabolism, modulate inflammatory reaction and inhibit atherosclerosis through activating peroxisome proliferator-activated receptors. Clinical-epidemiological study showed different opinions on whether sulfonylureas can increase the mortality of patients with cardiovascular diseases.