Nogo-A in the rat dorsal root ganglion promotes the polymerization of tubulin and inflammatory heat hyperalgesia / 解剖学报
Acta Anatomica Sinica
;
(6): 549-553, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-844599
ABSTRACT
Objective To investigate the regulation of microtubules by Nogo-A in the dorsal root ganglia during the inflammatory pain. Methods The ipsilateral paw withdrawal latency (PWL) was measured in wild type rats(WT, n = 12) and Nogo-A konck-out (Nogo-A KO) rats (n = 14) after complete Freunds adjuvant (CFA) injection. Western blotting and immunofluorescent staining were used to study the expression of microtubules and phosphorylated collapsin response mediator protein 2(p-CRMP2)in the dorsal root ganglion (DRG) of both groups. Results Knock out of Nogo-A in rats had'attenuated the CFA-induced inflammatory hyperalgesia. The acetylated tubulin was reduced, and the expression of p-CRMP2 was increased in the DRG of the Nogo-A KO rats. Conclusion Nogo-A is involved in the regulation of inflammatory heat hyperalgesia by promoting the microtubule polymerization via CRMP2 pathway.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Anatomica Sinica
Year:
2019
Type:
Article
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