Human protein tyrosine phosphatase β and its inhibitors: Research advances / 国际药学研究杂志

ABSTRACT

Human protein tyrosine phosphatase β (HPTPβ) is an endothelial cell-specific receptor protein tyrosine phosphatase(PTP). HPTPβ plays an important role in regulating pathophysiological processes such as angiogenesis and cell-to-cell adherens junction, and is taken as a novel target for developing new antiatherosclerosis and antitumor drugs. In this review, the latest research progress in the structure, physiological functions and small molecular inhibitors of HPTPβ is summarized.