Study on effect of compatibility on pharmacokinetics of Guizhi Zhumian prescription in cynomolgus monkeys based on Q-marker / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 3996-4002, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-846272
ABSTRACT
Objective:
To study the effect of compatibility on pharmacokinetics of the main components of Guizhi Zhumian prescription (GZP) based on the concept of Q-marker and to provide evidences for the determination of the Q-markers of this prescription.Methods:
UPLC-MS/MS method was established for the study of the pharmacokinetics behaviors of seven main components, including cinnamic acid, 4-methoxycinnamic acid, coumarin, gardenoside, genipin, geniposidic acid, and chlorogenic acid, before and after the compatibility of GZP in plasma of cynomolgus monkeys.Results:
Compared with the pharmacokinetics parameters of Cinnamomum cassia and Gardenia jasminoides, the AUC and Cmax of cinnamic acid, coumarin, geniposidic acid, and chlorogenic acid in GZP were increased obviously; The t1/2 of cinnamic acid, 4-methoxycinnamic acid, and coumarin were decreased; And the tmax of 4-methoxycinnamic acid, and geniposide were prolonged.Conclusion:
Compatibility of GZP could significantly change the in vivo exposure status of the main components, and the seven main compounds were determined to be the Q-markers of GZP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2020
Type:
Article
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