Study on chemical constituents of Abies chensiensis / 中草药

ABSTRACT

Objective: To study the chemical constituents of the sterns and leaves parts of Abies chensiensis. Methods: The isolation and purification were carried out by HP-20 macroporous resin, Sephadex LH-20, silica gel column chromatography, semi-preparative HPLC. Their structures were elucidated on the basis of physicochemical properties and spectroscopic data. Results: Twenty-four compounds were isolated and elucidated from the sterns and leaves parts of A. chensiensis, their structures were identified as 7,14,24-mariesatrien-26,23-olide-3α,23-diol (1), (23R)-3α-hydroxy-9,19-cyclo-9β-lanost-24-en-26,23-olide (2), 7-oxocallitrisic acid (3), 23-hydroxy-3-oxomariesia-8 (9),14,24-trien-26,23-olide (4), neoabiestrine E (5), 3-oxo-9β-lanosta-7,24-dien-26,23R-olide (6), 7,14,22Z,24-mariesatetraen-26,23-olide-3-one (7), (+)-rel-3α-hydroxy-23-oxocycloart-25 (27)-en-26-oic acid (8), cycloart-25-en- 3β,24-diol (9), neoabiestrine H (10), 3-oxo-24,25,26,27-tetranolanost-8-en-23-oic acid (11), abiesadine C (12), 13β-epidioxy-8 (14)-abieten-18-oic acid (13), dehydroabietic acid (14), 15-hydroxydehydroabietic acid (15), methyl 18-methoxydehydroabietate (16), 7β-hydroxy dehydroabietic acid (17), dehydroabietan-18-ol (18), centdaroic acid (19), abietic acid (20), 6,8,11,13-abi-etatrien-18-oic acid (21), abiesadine B (22), abiesadine N (23), 12β-hydroxyabietic acid (24). Conclusion: All compounds are isolated from the plants of A. chensiensis for the first time, and compound 11 is isolated from the Abies genus for the first time.