The characteristics of microparticles derived from leukocytes of patients with breast cancer and their clinical significance / 肿瘤

ABSTRACT

Objective: To explore the characteristics of leukocyte-derived microparticles (LMPs) in breast cancer patients and their clinical significance. Methods: The expressions of LMPs, CD44+ LMPs, CD24+ LMPs and CD44+ CD24- LMPs in peripheral blood of 44 breast cancer patients and 10 healthy volunteers were detected by using flow cytometry. The percentages of CD44+, CD24+ and CD44+ CD24- cells in monocytes (MNCs) of breast cancer pateints and healthy volunteers were further detected. The clinical relevance of LMPs, and the correlation between MNCs and LMPs were analyzed. Results: The percentages of LMPs, CD44+ LMPs and CD44+ CD24- LMPs in breast cancer patients were statistically higher than those in the healthy volunteers (P =0.021, P =0.011, and P =0.006, respectively). There was a statistical difference in the percentage of LMPs among the different tumor volunmes (P =0.018). Statistical difference was also obseved in the percentage of CD44+ LMPs among different Her-2 levels (P =0.020). The percentages of CD44+, CD24+ and CD44+ CD24- cells in MNCs in breast cancer patients were not statistically different from those in the healthy volunteers. There was no statistical correlation between MNCs and LMPs. Conclusion: The percentage of LMPs in breast cancer patients can be used to evaluate the tumor volume. The percentage of CD44+ LMPs was closely correlated with Her-2 level, and it can be used to evaluate the recurrence, metastasis and prognosis of breast cancer. Copyright© 2012 by TUMOR.