Clinical analysis of 32 cases of primary malignant germ cell tumors in mediastinum / 肿瘤

ABSTRACT

Objective: To analyze clinical features, treatment and prognosis of primary malignant germ cell tumors (MGCT) of mediastinum. Methods: Thirty-two patients with primary malignant germ cell tumors of mediastinum received multi-modality treatment such as surgery, radiotherapy and chemotherapy. There were 18 patients with seminomas and 14 patients with nonseminomatous germ cell tumors. Results: For patients with nonseminomatous germ cell tumors the median survival time was 32.4 months and the median progression-free survival (PFS) time was 18 months. Both the five-year disease free survival rate and the total survival rate were 28.6%. For patients with seminomas the five-year disease free survival rate was 83.3% and the total survival rate was 85.6%. And the median survival time and the progression-free survival time could not be calculated. Both the median survival time and the PFS time were longer in patients with seminomas than those with nonseminomatous germ cell tumors (P = 0. 0014 and 0. 0007, respectively). Conclusion: Multi-modality treatment for patients with primary mediastinal seminomas achieves better clinical outcomes. Our results are in accordance with others work reported in the literature. The therapeutic efficacy for nonseminomatous germ cell tumors should be improved. Nonseminomatous germ cell tumor is an important prognostic factor for mediastinal malignant tumors.