Advanced glycation end products in chronic kidney disease: Pathogenic role and preventive strategy / 解放军医学杂志

ABSTRACT

Advanced glycation end products (AGE) are stable compounds produced by spontaneous non-enzymatic reaction between reducing sugars and proteins, and have been proven recent years to be associated with a variety of chronic diseases. AGE can exacerbate the progression of chronic kidney disease (CKD) by altering the physiological function of proteins, triggering cellular cascade reaction, leading to the disintegration of the filtration barrier, causing oxidative stress and renal fibrosis. The progression of CKD, in turn, leads to a decline in renal function, followed by further accumulation of AGE due to a decrease in glomerular filtration rate, forming a vicious circle. The role of AGE in the occurrence and development of CKD is a hot topic in recent years. Here's a description of AGE biochemical characteristics, related cellular events, role in CKD development, and current research progress on AGE therapy.