Studies on chemical constituents and bioactivities of alkaloids from zanthoxylum schinifolium / 中草药

ABSTRACT

Objective: To study the chemical structure and bioactivity of the alkaloids from Zanthoxylum schinifolium. Methods The alkaloids were isolated and purified by silica gel, Sephadex LH-20 column chromatography, recrystallization, and semi-preparetive HPLC. Their structures were elucidated by physical and spectroscopic analysis. The cytotoxic activity of these compounds were tested by MTS. Results Nine alkaloids were obtained and identified as dictamnine (1), skimmianine (2), schinifoline (3), 6-methoxy-furanoquinolone (4), (+)-(S)-isoplatydesmine (5), (+)-(S)-araliopsine (6), (−)-(S)-ribalinine (7), (−)-(S)-edulinine (8), and (−)-(S)-6-acetonyldihydrochelerythrine (9). Conclusion Compound 4 is a new natural product and compounds 5—9 are isolated from this plant for the first time. Compound 9 has potential cytotoxicity towards HL-60, SMMC-7721, and A549.