Preparation and bioavailability of curcumin/piperine solid dispersions / 中草药

ABSTRACT

Objective Solid dispersion of curcumin and piperine compositions (CUR-PIP SD) was prepared to increase the in vitro dissolution rate and the oral bioavailability of CUR and PIP. Methods The CUR-PIP SD was prepared by a solvent evaporation method with dissolution rate as index. The characterization of CUR-PIP SD was evaluated by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), and the resulting SD was evaluated by in vitro dissolution assay. UPLC-MS/MS was used to determine the plasma concentrations of CUR and PIP in rats after ig administration. Results In vitro dissolution experiments showed that the dissolution rate of CUR and PIP in SD were both greatly improved compared with that of raw materials. Oral bioavailability of CUR in the SD was 2.71 times of that of the drug substance (P < 0.05), and PIP was increased to 2.68 times (P < 0.05). Conclusion The SD prepared with PVP K30 can effectively increase the in vitro dissolution and bioavailability of CUR and PIP.