Study on prescription technology of compound Aloe vera L. polysaccharide gel and in vitro release characteristics / 中草药

ABSTRACT

Objective: To optimiaze the preparation technology of compound Aloe vera L. polysaccharide gel (CAVPG), and evaluate the in vitro release characteristics. Methods: with the appearance of the blank gels, spreadability, viscosity, high temperature stability (place 55℃ water bath for 5 h), low temperature stability (place −20℃ water bath for 24 h) as examining index, screening gel matrix preliminary; With the release degree of aloe polysaccharide, nano-silver, nano-zinc as examining index, investigating the release degree of aloe polysaccharide, nano-silver, nano-zinc in different substrates, determining the gel matrix; the orthogonal test was used to optimize the prescription craft, with the substrate consumption, glycerin dosage, mixing temperature for investigation factors. With the cumulative release degree of AVP, nano-silver and nano-zinc as index, stirring basket method was adopted to determine the cumulative release degree of AVP, nano-silver and nano-zinc. The curve of drug release in vitro was fitted with different release model to estimate the in vitro release characteristics of CAVPG. Results: The optimum prescription process was Aloe vera L. Polysaccharide 2%, nano-silver 1%, nano-zinc 1%, carbomer-980 0.5%, glycerol 5%, a moderate amount of triethanolamine, with PBS buffer up to 100 g, mixing temperature 25℃; Compared with other in vitro release models, zero order equation was the fittest model to nano-silver and nano-zinc, the primary equation was the fittest model to AVP. Conclusion: The gels of CAVPG prescription is reasonable, the prescription craft is simple, the quality is controllable. It has a development prospect.