Comparative study of effects of Sini Decoction before and after compatibilities on experimental myocardial ischemia in rats / 中草药

ABSTRACT

Objective: To study the effects of Sini Decoction before and after compatibilities on acute myocardial ischemia rats. Methods: The model of myocardial ischemia in rats was established by ig Pit. The effects of Sini Decoction, Aconiti Lateralis Radix Praeparata (ALRP)-Glycyrrhizae Radix et Rhizoma (GRR) decoction, ALRP-Zingiberis Rhizoma (ZR) decoction, ZR-GRR decoction, single ALRP decoction, single ZR decoction and single GRR decoction on the extension of myocardial infarction, lactic dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), and lactic acid in rats were evaluated. Results: Sini Decoction, ALRP-GRR decoction, ALRP-ZR decoction, and single ALRP decoction obviously decreased the extension of myocardial infarction (P ALRP-ZR decoction > ALRP-GRR decoction > single ALRP decoction. It reveals the scientific connotation of the compatibilities of Sini Decoction and accurate action about drug using of Sini Decoction from the perspective of efficacy.