Effect of Aconiti Lateralis Radix Preparata on hemodynamics of rats with acute heart failure and its mechanism / 中草药
Chinese Traditional and Herbal Drugs
; (24): 3223-3227, 2015.
Article
in Zh
| WPRIM
| ID: wpr-853897
Responsible library:
WPRO
ABSTRACT
Objective:
To observe the effects of Aconiti Lateralis and Radix Preparata (ALRP) on hemodynamic indexes of rats with acute heart failure (AHF) and to study its possible mechanism of α and β adrenergic receptor-related action.Methods:
The AHF model in Wistar rats was induced by injecting large doses of pentobarbital. Rats were received high and low doses of ALRP as well as α and β adrenergic receptor blockers to observe the effect on hemodynamics (LVSP, HR, and ±dp/dtmax) in rats.Results:
ALRP could significantly increase blood pressure, heart rate, and myocardial contractility compared with the control group (P < 0.05, 0.01), and it also exhibited a certain degree of volume-efficiency and time-effect relationship. The pressor effect of ALRP could be significantly reduced by α and β adrenergic receptor blockers. Moreover the increasing heart rate effect of ALRP could be significantly reduced by β adrenergic receptor blocker (P < 0.05, 0.01).Conclusion:
ALRP can significantly enhance the cardiac function in rats with AHF and the possible mechanism of this effect is associated with α and β adrenergic receptors.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Traditional and Herbal Drugs
Year:
2015
Type:
Article