Preparation of scutellarin-piperine co-amorphous complex and its in vitro release / 中草药

ABSTRACT

Objective: To prepare scutellarin-piperine co-amorphous complex, in order to improve their dissolution and solubility. Methods: Scutellarin-piperine co-amorphous complex was prepared using solvent evaporation method. The microscopic structure and physicochemical properties of co-amorphous complex were analyzed using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray powder diffraction (XRD), and infrared vibrational spectra (IR). And its in vitro release also was investigated. The formation of the co-amorphous complex in scutellarin and piperine was studied. Results: DSC and XRD analysis suggested that scutellarin and piperine may be present as amorphous substance. IR results indicated molecular interactions between scutellarin and piperine. The in vitro release determination results of scutellarin-piperine co-amorphous complex showed accumulated dissolution rate of scutellarin and piperine could both be improved. Conclusion: The drug-drug co-amorphous system can provide certain reference for insoluble drugs to improve their dissolution and solubility.