Comparative studies on anti-inflammatory and analgesic activities of different fractions from Isatidis Radix / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2517-2521, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-854890
ABSTRACT
Objective:
To observe the anti-inflammatory and analgesic activities of the different fractions from Isatidis Radix.Methods:
The anti-inflammatory effects were observed by a in vitro model of LPS-stimulated RAW264.7 macrophages, and the analgesic effects were evaluated by the writhing test and the tail-immersion test in mice.Results:
The water extract, 30%, 50%, and 70% ethanol extracts of Isatidis Radix all had anti-inflammatory and analgesic activities. The 50% and 70% ethanol extracts were the main anti-inflammatory effective fractions. The water extract and 70% ethanol extract were the main analgesic effective fractions.Conclusion:
Different fractions of Isatidis Radix all have anti-inflammatory and analgesic activities, and the 70% ethanol extract has stronger activities. The mechanism of the anti-inflammatory and analgesic activities of the 70% ethanol extract may be related to the inhibition of the release of TNF-α and PGE2 from macrophages.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2014
Type:
Article
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