Preparation of curcumin thermoresponsive nanogels and their characteristics / 中草药
Chinese Traditional and Herbal Drugs
; (24): 2234-2239, 2013.
Article
in Zh
| WPRIM
| ID: wpr-855177
Responsible library:
WPRO
ABSTRACT
Objective:
To prepare curcumim thermoresponsive nanogels and study its release characteristics in vitro.Methods:
Poly (N-isopropyl acrylamide) (PNIPAm) thermoresponsive nanogels were synthesized by emulsion polymerization method, and then curcumin loaded-PNIPAm nanogels were prepared. The characteristics of PNIPAm nanogels, the drug loading, and the drug release in vitro were investigated.Results:
Atomic force micriscopy (AFM) observation showed that PNIPAm nanogels were spherical in shape with homogenous size. Moreover, PNIPAm No. 5 showed a high drug loading (27%). In vitro release study revealed that the 24 h accumulative in vitro release reached 75.2%.Conclusion:
The method used to prepare curcumin thermoresponsive nanogels is simple. It is expected to become a novel vehicle potentially nanoparticle drug delivery system of curcumin.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Traditional and Herbal Drugs
Year:
2013
Type:
Article