Impact of serum brain-derived neurotrophic factor levels on depression of hypertensive cerebral hemorrhage patients with conservative treatment / 中国脑血管病杂志

ABSTRACT

Objective: To investigate the impact of serum brain-derived neurotrophic factor (BDNF) levels on depression of hypertensive cerebral hemorrhage(HICH) patients with conservative treatment. Methods: From April 2014 to December 2017, a total of 63 patients with HICH hospitalized in the Department of Neurosurgery, Tangshan Gongren Hospital were enrolled. There were 38 males and 25 females patients. All had intracranial hematoma volume within 30 ml and received conservative treatment. Serum BDNF levels were detected using enzyme linked immunosorbent assay. The paralysis grade was assessed using National Institutes of Health Stroke Scale (NIHSS) on admission and the 21 st day after admission. The Zung Depression Self-rating Scale(SDS) was used to evaluate depression 21 days after admission. Patients with SDS score ≥53 were divided into the depression group and with SDS score < 53 were divided into the non-depression group. The differences of serum BDNF levels between the two groups were compared. Risk factors for depression of HICH patients with conservative treatment were analyzed by binary Logistic regression analysis. Results: The SDS score of the depression group (54. 7 ± 1.5) on the 21st day after admission was significantly higher than that of the non-depression group (44. 6 ± 6. 5, 1 =7. 020, P <0. 01). The serum BDNF levels of the depression group was lower than that of the non-depression group(7. 0 ± 1. 4 p, g/L vs. 8. 6 ± 1. 8 p, g/L, t = - 3. 433, P = 0. 001). The paralysis grade of the depression group was higher than that of the non-depression group on the 21st day after admission (5. 4 ± 1. 5 vs. 3. 8 ± 1. 1, t =4. 951, P <0. 01). In the depression group, the serum BDNF level was negatively correlated with SDS score(r = -0. 535, P =0. 013).blood loss(r= - 0. 578, P = 0. 006) and paralysis grade(r= -0. 715, P<0. 01) on the 21st day after admission. In binary Logistic regression analysis, serum BDNF level was a protective factor for depression in HICH patients undergoing conservative treatment(OR, 0. 990, 95% CI 0. 983-0. 997, P = 0. 008). Conclusion: The lower the serum BDNF levels of HICH patients with conservative treatment, the more prone to depression.