Risk factors for cerebral microbleeds and its effect on cognitive function in patients with ischemic cerebrovascular disease / 中国脑血管病杂志

ABSTRACT

Objectives: To investigate the occurrence and risk factors of cerebral microbleeds on the cognitive function in patients with ischemic cerebrovascular disease and to investigate the effect of cerebral microbleeds on the cognitive function in patients with ischemic cerebrovascular disease. Methods: A total of 160 patients with ischemic cerebrovascular disease were divided into cerebral microbleed group (n =30) and control group (n = 130) according to MR T2 *-weighted gradient echo sequences. The demographic data of the patients, conventional risk factors, sites of microbleed, types of cerebral infarction, severity of white matter changes, and numbers of lacunar infarction were recorded in detail. The Montreal Cognitive Assessment was conducted in both groups. All the data were processed using SPSS 16.0 software. Results: Circled digit oneThe mean age of the microbleed group was older than that in the non-microbleed group (75 ±9 vs. 66 ±6, P = 0.000) ; the degree of white matter changes was higher (6.7 ±2.4 vs. 3.5 ±1. 8, P =0.003) ; and the numbers of lacunar infarction were larger (5.0 ±2. 3 vs. 2. 1 ±1.3, P= 0.000). Circled digit twoThe logistic regression analysis showed that the high blood cholesterol, the degree of white matter change ( WMC ) , and the numbers of lacunar infarction were the independent risk factors for CMB (OR =3. 880, 95% CI:0. 086 -0. 994; OR = 11.735, 95% CI; 1.340 -2.930; OR = 10. 160, 95% CI: 1.241 -2.475). Circled digit threeThere was no significant difference in the cognitive function scores between the two groups ( P > 0. 05 ). Circled digit fourThere was significant difference in the executive ability between the two groups (P =0.010). Conclusions: Circled digit oneCerebral microbleeds are closely associated with leukoaraiosis and lacunar infarction; Circled digit twothe patients with ischemic cerebrovascular disease accompanied by microbleeds has obvious executive dysfunction ; Circled digit threecontrolling the risk factors for microbleeds has a certain role for the control of the occurrence and development of cognitive impairment in patients with ischemic cerebrovascular disease.