Serum transferrin as a liver fibrosis biomarker in patients with chronic hepatitis B
Clinical and Molecular Hepatology
; : 347-354, 2014.
Article
in En
| WPRIM
| ID: wpr-85685
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS: Transferrin and alpha-1 antitrypsin are reportedly associated with liver fibrosis. We evaluated the usefulness of serum transferrin and alpha-1 antitrypsin as new liver fibrosis markers in patients with chronic hepatitis B. METHODS: The study included 293 patients with chronic hepatitis B who underwent a liver biopsy between October 2005 and June 2009, and who had no history of hepatocellular carcinoma. Serum markers and liver fibrosis stages were compared. RESULTS: Univariate analysis revealed that age (P<0.001), serum platelet count (P<0.001), and serum alkaline phosphatase level (P=0.003) differed significantly between the patients with and without liver cirrhosis. Serum transferrin levels were significantly lower in advanced fibrosis than in mild fibrosis in both univariate analysis (P=0.002) and multivariate analysis (P=0.009). In addition, the serum transferrin level was significantly lower in cirrhotic patients than in noncirrhotic patients (P=0.020). However, the serum level of alpha-1 antitrypsin was not significantly associated with liver cirrhosis in patients with chronic hepatitis B. CONCLUSIONS: Serum transferrin could be promising serum marker for predicting advanced liver fibrosis in patients with chronic hepatitis B.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Biomarkers
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Alpha 1-Antitrypsin
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Multivariate Analysis
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Retrospective Studies
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ROC Curve
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Area Under Curve
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Hepatitis B, Chronic
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Transferrins
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Liver Cirrhosis
Type of study:
Observational_studies
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Prognostic_studies
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Language:
En
Journal:
Clinical and Molecular Hepatology
Year:
2014
Type:
Article