Research progress of signaling transduction pathway mediated by tgr5 / 中国药理学通报

ABSTRACT

GPCBAR1, also known as TGR5 receptor, is one member of the GPCRs family. TGR5, a pattern recognition receptor located on cell membrane, is widely expressed in human beings and animals, playing numerous significant roles in anti-inflammation and immune regulation, energy metabolism, glucose metabolism and anti-cancer. Many signaling pathways are induced by TGR5 upon activated. AKT, NF-kB, ERK, STAT3, cAMP signaling pathways, methods and results of TGR5-mediated signaling pathways and t(ie development of new drugs via TGR5-mediated signaling pathways were reviewed in this paper.