Research progress of RNA-binding motif protein 20 in cardiomyopathy / 中国药理学通报

ABSTRACT

Cardiomyopathy is a heterogeneous heart disease characterized by abnormalities in myocardial structure and function, which ultimately leads to heart failure even death. RNA-binding motif protein 20 (RBM 20) is a family of serine/arginine-rich proteins, highly expressed in heart. It plays an important role in the assembly and alternative splicing of RNA spliceosome, and participates in the development of cardiomyopathy. RBM 20 regulates the alternative splicing of Titin, RyR 2, LDB 3, CaMKIIô, CACNA1C involved in diastolic function, sarcomere assembly and ion transport. In this review, the role of RBM 20 in cardiomyopathy and the regulatory mechanisms of RBM 20 is summarized.