Research on anti-tumour activity of 2-( N-propylamine)-6-trifluoromethoxy-benzothiazoIe / 中国药理学通报

ABSTRACT

Aim To study the anti-tumour activity and mechanism of 2-( N-propylamine )-6-trifluoromethoxy-benzothiazole. Methods The anti-proliferative activities against HeLa, HepG2, MCF-7 and SP2/0 cancer cell lines were assessed by CCK-8 assay. The morphological changes of cancer cells were observed by Ho-echst staining. Effects on the cell migration were evaluated by monolayer cells wound healing assay. The cell apoptosis analysis was evaluated by using the flow cytometric analysis. Results Compound 2-(N-propylamine)-6-trifluoromethoxy-benzothiazole showed good selectivity and inhibitory effects against four tumor cell lines. Especially, the effects on MCF-7 cells were very significant. This compound could inhibit the migration of MCF-7 cells and induce early apoptosis. Conclusions 2-(N-propylamine)-6-trifluoromethoxy-benzothi-azole can inhibit the proliferation of four tumor cell lines. It shows inhibitory effects on MCF-7 cells by inducing early apoptosis.