Energy metabolism mechanism of Xiaoyaosan in treatment of depression based on integrative pharmacology-based research platform of traditional Chinese medicine / 中国药理学与毒理学杂志

ABSTRACT

Objective: To predict the action targets of antidepressant active ingredients of Xiaoyaosan in order to find out more about the "multi-component, multi-target and multi-pathway" mechanism. Methods: The target-disease target network of Xiaoyaosan antidepressant was constructed by using the integrative pharmacology- based research platform of traditional Chinese medicine. The key nodes were screened by network analysis method, and the pathway enrichment analysis of the key nodes was carried out on the basis of the network analysis method to explore its possible biological process in the treatment of depression. Results: Many components of Xiaoyaosan had antidepressant properties through ATPase Na+K+transporting subunit alpha 1, ATP synthase subunit alpha, beta and gamma targets, involving tricarboxylic acid cycle, carbohydrate metabolism, amino acid metabolism, serotonergic synapse and oxidative phosphorylation pathways. Conclusion: Xiaoyaosan plays an antidepressant role in regulating the energy metabolism through "the multi-component and multi-target" model.