Aspirin bilayer tablets prepared with 3D printer for drug controlled release / 中国药学杂志

ABSTRACT

OBJECTIVE: Taking aspirin as a model drug, the feasibility of the controlled release of aspirin tablets was discussed, which was based on the individual demand of 3D printing technology. METHODS: The experiment selected 10 000 mPa·s hydroxypropyl methyl cellulose (HPMC10000) and polyacrylic acid (PAA) as a hydrophilic matrix sustained-release layer; hydroxypropyl methyl cellulose 100 mPa·s (HPMC100) as a quick release layer binder, sodium carboxymethyl starch (CMS-Na) and sodium carboxymethyl starch (SSG) as a quick release layer disintegrating agent, the use of 3D printer to print the slow release of aspirin tablets. Select 100 mg·mL-1 and polyvinylpyrrolidone (PVPK30) as a quick release layer binder, crosslinking sodium carboxymethyl cellulose (CC-Na) as a quick release layer disintegrating agent, hydroxypropyl methyl cellulose (HPMC100) as the matrix material release layer, with the traditional press pressing speed of aspirin sustained-release tablet, as contrast agents. The physical and chemical properties of tablets produced in two different modes of production (film weight difference, hardness and thickness) and release profile were investigated. RESULTS: The physical and chemical properties of the two tablets are all in the Pharmacopoeia. Comparison of two kinds of drug release curve showed that the ASA-HPMC (14%, ω) and the press release curve of double layer tablets printing film is similar, and the release rate is higher than the tablet (6% ω. ASA-HPMC double layer tablets), ASA-HPMC (8%, ω) and ASA-HPMC (10%, ω) printing film final release amount increased with hydrophilic matrix HPMC. CONCLUSION: 3D printers print different shapes of tablets with different release profiles, in which the release of the package is higher than the other tablets.