Preparation process of liquiritigenin injection / 中国药学杂志

ABSTRACT

OBJECTIVE: To optimize the preparation process of liquiritigenin injection. METHODS: Single factor experiment was carried out to determine the solvents, dosage of adjuvants, pH of solution, pyrogen removal method and sterilization process. RESULTS: The optimal conditions were determined as follows: liquiritigenin was dissolved in 40% propylene glycol solution at pH 4.0-6.0. Ultrafiltration was employed to remove bacterial endotoxin. The solution was sterilized at 121℃ (97 kPa) for 15 min. CONCLUSION: The established preparation process of liquiritigenin injection is reasonable and suitable for industrialized production.