Inclusion of quercetin in amino-group modified ordered mesoporous silica: drug loading and release properties / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 894-898, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-860367
ABSTRACT
OBJECTIVE:
To prepare amino-modified ordered mesoporous silica (NH2-OMS) as a drug carrier and test the loading and release properties of poorly water soluble drug carried by it.METHODS:
OMS was first prepared using cetyltrimethyl ammonium bromide as the template and then modified by 3-aminopropyl trimethoxy silane to prepare NH2-OMS. N2 adsorption-desorption, X-ray diffraction and thermogravimetric analysis were used to characterize the NH2-OMS. Quercetin was loaded onto NH2-OMS in order to explore the drug loading properties of NH2-OMS.RESULTS:
The drug loading and entrapment efficiency of quercetin-NH2-OMS were about 21.0% and 58.2%, respectively, when the concentration of quercetin was 4 mmol·L-1, the reaction time was 24 h and the temperature was set at 50°C. The in vitro release test demonstrated that quercetin-NH2-OMS could form supersaturated solution in simulated intestinal fluid and gastric fluid at concentrations of 13-fold and 27-fold of the thermodynamic solubility of quercetion.CONCLUSION:
NH2-OMS, as the carrier for quercetin, can significantly increase its water solubility and release rate in intestinal and gastric fluids.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS