Synthesis of arachidic acid-cholic acid conjugate aramchol for treating disordered lipid metabolism / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 920-924, 2013.
Article
in Zh
| WPRIM
| ID: wpr-860373
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: To optimize the process of synthesizing aramchol. METHODS: Using arachidic acid (eicosanoic acid) and cholic acid as the starting materials, 3β-arachidyl-amido-7α, 12α-dihydroxyl-5β-cholanic-24-acid, a fatty acid bile acid conjugate aramchol, was synthesized through a 9 step route in which the carboxyl group and hydroxyl groups of cholic acid has been orthogonally protected and regioselectively deprotected. RESULTS: The yield of the target product was 12.7%. CONCLUSION: With reproducibile reactions, less by-products, and mild, controllable and relatively safe conditions, the improved process is very suitable for lab-scale production.
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WPRIM
Language:
Zh
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article