Comparison of sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 392-394, 2013.
Article
in Zh
| WPRIM
| ID: wpr-860466
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To compare the efficacy, compliance, safety and economics of standard triple therapy and 10-day sequential therapy consisting of rabeprazole, clarithromycin, amoxicillin and tinidazole for Helicobacter pylori eradication.METHODS:
A total of 90 pepticulcer patients who were Helicobacter pylori positive proved by C-urea breath test (C-UBT) were randomly divided into two groups. Forty-five patients received rabeprazole-based 10-day sequential therapy and the other forty-five patients received rabe-prazole-based 7-day standard triple therapy. C-UBT was carried out 4weeks after a course of treatment to evaluate the eradication of Helicobacter pylori. The two regimens were evaluated by cost-effectiveness analysis.RESULTS:
Eighty-five patients completed the study. The Helicobacter pylori eradication rates by intention-to-treat (ITT) analysis and by per-protocol (PP) analysis in 10-day sequential therapy group were higher than those in 7-day standard triple therapy group (ITT 91.1% vs. 73.3%, P<0.05; PP 95.3% vs. 78.6%, P<0.05). The incidences of adverse reactions (PP 14.0% vs. 11.9%, P<0.05) were similar in the two groups. The cost-effectiveness analysis showed that the C/E value of the 10-day sequential therapy were lower.CONCLUSION:
Rabeprazole-based 10-day sequential therapy is more effective for eradication of Helicobacter pylori.
Full text:
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Index:
WPRIM
Type of study:
Guideline
Language:
Zh
Journal:
Chinese Pharmaceutical Journal
Year:
2013
Type:
Article