Survival and prognosis of 60 cases with appendix-derived high-grade mucinous adenocarcinoma / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 492-495, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-861604
ABSTRACT
Objective:
To investigate the clinical characteristics and prognostic factors associated with appendix-derived high-grade mucinous adenocarcinoma.Methods:
A retrospective analysis of clinical and follow-up data of 60 patients with appendix-derived high-grade mucinous adenocarcinoma admitted to Aerospace Central Hospital between January 2013 and December 2017 was carried out.Results:
Of the patients, 48% (29 cases) were men and 52% (31 cases) were women. The median age of the patients at admission was 57 (38-74) years. CEA levels increased in serum in 65% patients (39 cases) before operation, and hyperthermic intraperitoneal chemotherapy after operation accounted for 80% of the patients (48 cases). The 1-, 2- and 3-year survival rates were 80%, 58%, and 30%, respectively. The median survival time was 29 months. Univariate analysis showed that a lower peritoneal cancer index (PCI) score (P= 0.039) and a lesser degree of completeness of cytoreduction (CC) (P=0.002) were statistically significant in prolonging survival time. Multivariate analysis showed that the degree of CC could be an independent prognostic factor for overall survival (P=0.037).Conclusions:
Appendix-derived high-grade mucinous adenocarcinoma is highly invasive and features a poor prognosis, but radical tumor reduction has a positive effect on prolonging the survival of patients. Early detection and early intervention are of great significance for the prognostic outcome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
/
Screening study
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2020
Type:
Article
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