Research Progress in Effects of Mechanical Factors on Angiogenesis of Vascular Endothelial Cells and the Mechanism / 医用生物力学

ABSTRACT

The angiogenic capacity of vascular endothelial cells is influenced by multiple mechanical factors. Mechanical factors guide the rearrangement of cytoskeleton, mediate intracellular signal transduction, affect cell migration, orientation and other behaviors, and then regulate their angiogenic capacity. However, different types of mechanical stimulation have different effects on their angiogenic capacity. This article summarizes and discusses the research work and progress of the influence of five mechanical factors （shear force, stretch stress, low-intensity pulsed ultrasound, microgravity, material properties） on vascular endothelial cell angiogenesis, which provides a basis and ideas for in-depth research of vascular biomechanics.