Loss of Heterozygosity at 3p in Korean Non-Small Cell Lung Cancer / 결핵
Tuberculosis and Respiratory Diseases
; : 975-983, 1998.
Article
in Ko
| WPRIM
| ID: wpr-86318
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Frequent deletion of 3p in numerous cancer including lung cancer suggests the presence of tumor suppressor gene. 3p has been analysed by RFLP and PCR-LOH of microsatellite locus. In this study, we observed the deletion of 3p in Korean NSCLC by PCR-LOH of 4 microsatellite loci and investigated the clinical significance.Method:
62 surgically rejected NSCLC DNA and normal lung DNA have been analysed by PCR-LOH at three dinucleotide[D3S1228 (3p14.1-14.3), D3S1067 (3p14.3-21.1), D3S1029 (3p21.1-21.3)] and one tetranucleotide[D3S1537 (Sp 22-24.2)] repeat microsatellite loci.RESULTS:
Among 59 informative cases, 3p deletion by PCR-LOH at four microsatellite loci was found in 31 patients (52.5%). 3p deletion were found in 55% of squamous cell lung cancer and 47% of adenocarcinoma patients. No significant difference has been found in clinical parameters such as staging, smoking and survival according to the status of 3p deletion.CONCLUSION:
Deletions in 3p have played an important role in Korean NSCLC though no clinical significance was detected.Key words
Full text:
1
Index:
WPRIM
Main subject:
Smoke
/
Polymorphism, Restriction Fragment Length
/
DNA
/
Adenocarcinoma
/
Smoking
/
Genes, Tumor Suppressor
/
Carcinoma, Non-Small-Cell Lung
/
Microsatellite Repeats
/
Loss of Heterozygosity
/
Lung
Limits:
Humans
Language:
Ko
Journal:
Tuberculosis and Respiratory Diseases
Year:
1998
Type:
Article