Diagnosis value of microRNA-21/29a and D-dimer in myocardial ischemia-reperfusion / 中国医师进修杂志

ABSTRACT

Objective:To investigate the diagnostic value of micro RNA (miR)-21, miR-29a and D-dimer in myocardial ischemia-reperfusion.Methods:The clinical data of 80 patients with myocardial ischemia-reperfusion (ischemia-reperfusion group) and 80 patients without coronary artery stenosis (control group) in Yueqing People′s Hospital, Zhejiang Province from May 2017 to October 2018 were retrospectively analyzed. The patients in ischemia-reperfusion group were treated with percutaneous coronary intervention (PCI). The levels of miR-21, miR-29a, D-dimer, cardiac troponin (cTN), high sensitive C-reactive protein (hs-CRP) and N-terminal pro brain natriuretic peptide (NT-proBNP) were measured in the ischemia-reperfusion group before operation, 1 and 5 d after operation, and the indexes in control group were measured on the day of admission.Results:In control group, the miR-21, miR-29a, D-dimer, cTn, hs-CRP and NT-proBNP were 0.14 ± 0.03, 0.19 ± 0.07, (123.2 ± 23.1) μg/L, (0.02 ± 0.01) μg/L, (0.65 ± 0.23) mg/L and (160 ± 78) ng/L. In ischemia-reperfusion group, the indexes before operation were 0.36 ± 0.08, 0.30 ± 0.05, (812.2 ± 95.7) μg/L, (0.48 ± 0.07) μg/L, (5.36 ± 2.67) mg/L and (853 ± 462) ng/L; the indexes 1 d after operation were 0.31 ± 0.07, 0.26 ± 0.04, (685.0 ± 29.3) μg/L, (0.41 ± 0.09) μg/L, (4.28 ± 1.59) mg/L and (560 ± 256) ng/L; the indexes 5 d after operation were 0.22 ± 0.03, 0.20 ± 0.04, (216.0 ± 27.6) μg/L, (0.30 ± 0.06) μg/L, (2.36 ± 0.78) mg/L and (382 ± 136) ng/L. The miR-21, miR-29a, D-dimer, cTn, hs-CRP and NT-proBNP before operation and 1, 5 d after operation in ischemia-reperfusion group were significantly higher than those in control group, and there were statistical differences ( P<0.05). In ischemia-reperfusion group, the indexes 1 and 5 d after operation were significantly lower than those before operation, the indexes 5 d after operation were significantly lower than those 1 d after operation, and there were statistical differences ( P<0.05). Conclusions:miR-21, miR-29a, D-dimer, cTn, hs-CRP and NT-proBNP are closely related to the clinical myocardial ischemia-reperfusion state.