Fluorescence imaging of drug target proteins using chemical probes / 药物分析学报
Journal of Pharmaceutical Analysis
;
(6): 426-433, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-865662
ABSTRACT
Fluorescence imaging can provide valuable information on the expression, distribution, and activity of drug target proteins. Chemical probes are useful small-molecule tools for fluorescence imaging with high structural flexibility and biocompatibility. In this review, we briefly introduce two classes of fluorescent probes for the visualization of drug target proteins. Enzymatically activatable probes make use of the specific enzymatic transformations that generally produce a fluorogenic response upon reacting with target enzymes. Alternatively, specific imaging can be conferred with a ligand that drives the probes to target proteins, where the labeling relies on noncovalent binding, covalent inhibition, or traceless la-beling by ligand-directed chemistry.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Pharmaceutical Analysis
Year:
2020
Type:
Article
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