Changes of serum cytokines in patients with Kaschin-Beck disease treated with three treatment methods / 中华地方病学杂志

ABSTRACT

Objective:To investigate the effects of 3 treatment methods on serum cytokines in Kaschin-Beck disease (KBD) patients.Methods:In May 2015, according to "Diagnosis of Kaschin-Beck disease" (WS/T 207-2010), KBD patients with grade Ⅰ and above who lived in KBD areas of Guide, Xinghai and Banma counties of Qinghai Province for at least 25 years and aged 25 - 62 years old were selected as research subjects. Patients were divided into 3 groups according to different treatment methods. The first group ( n = 91) was treated with Celecoxib + Xiaohuoluo pill (concentrated pill), the second group ( n = 89) was treated with Celecoxib + bone-strengthening joint pill, and the third group ( n = 94) was treated with Celecoxib + anti-osteogenic tablet, and the overall treatment effects of 6 months after treatment of the 3 groups were compared and analyzed. The contents of serum nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β) and hyaluronic acid (HA) in patients before and after treatment were detected by enzyme-linked immunosorbent assay (ELISA). Results:A total of 274 KBD patients were included, aged (47.24 ± 18.97) years old, including 132 males and 142 females. The treatment effective rates in the first, second and third groups were 80.22% (73/91), 77.53% (69/89) and 77.66% (73/94), respectively, and there was no significant difference between the three groups (χ 2 = 0.25, P > 0.05). Before and after the treatment, the serum NO contents of the 3 groups [(149.23 ± 20.61), (135.88 ± 29.63), (151.33 ± 22.15), (137.55 ± 31.51), (148.58 ± 24.36), (134.81 ± 28.53) μmol/L] were significantly different ( t = 2.678, 2.403, 3.195, P < 0.05), and there were no significant differences in TNF-α, IL-1β, and HA contents ( P > 0.05). Conclusion:Three treatment methods for treating KBD have achieved certain effects, all the 3 treatment methods have reduced serum NO content and have no significant effect on TNF-α, IL-1β and HA contents.