Analysis of dyslipidemia and related factors in adult patients with brucellosis / 中华地方病学杂志
Chinese Journal of Endemiology
; (12): 815-820, 2020.
Article
in Zh
| WPRIM
| ID: wpr-866213
Responsible library:
WPRO
ABSTRACT
Objective:
To understand the characteristics of brucellosis in adults and the abnormality of blood lipid profile, and to analyze the related factors of dyslipidemia in brucellosis patients, so as to provide reference for preventing and controlling the potential risk of dyslipidemia in brucellosis patients.Methods:
The clinical data of all hospitalized patients with brucellosis diagnosed in Liaoning Provincial Hospital of Infectious Diseases from January 1, 2015 to December 31, 2016 were collected. Patients' general demographic characteristics, exposure history, clinical stage and course of disease, concomitant chronic diseases and other basic conditions and dyslipidemia were analyzed; single factor and multivariate unconditional logistic regression models were used to analyze the related factors of dyslipidemia in patients with brucellosis.Results:
A total of 562 cases with brucellosis were collected, aged (48.59 ± 12.26) years old, ranging from 18 to 76 years old, and the male to female ratio was 2.5∶1.0 (402∶160); among them, 193 cases (34.3%) had a history of contact with cattle and 331 cases (58.9%) had a history of contact with sheep. Among the 562 cases of brucellosis, 314 cases (55.9%) were accompanied with dyslipidemia, 48 (8.5%), 152 (27.0%), 60 (10.7%) and 217 (38.6%) with abnormal total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), respectively. The results of logistic regression analysis showed that diabetes [odds ratio ( OR) = 4.201, 95% confidence interval ( CI) 1.361-12.971], elevated neutrophils ( OR = 2.314, 95% CI 1.981-5.462), elevated alanine transferase ( OR = 2.188, 95% CI 1.379-3.473), increased procalcitonin ( OR = 1.707, 95% CI 1.515-2.532), history of contact with cattle ( OR = 2.170, 95% CI 1.464-3.125) were risk factors of dyslipidemia in patients with brucellosis; and neutropenia ( OR = 0.458, 95% CI 0.232-0.904) was a protective factor.Conclusions:
The incidence of dyslipidemia in brucellosis patients is high. Diabetes, inflammation, abnormal liver function, and history contact with cattle are related factors for dyslipidemia in patients with brucellosis. Targeted measures should be taken to intervene and control the potential risk of dyslipidemia in patients with brucellosis, so as to reduce the burden of brucellosis and non-infectious chronic diseases.
Full text:
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Index:
WPRIM
Type of study:
Prognostic_studies
/
Risk_factors_studies
Language:
Zh
Journal:
Chinese Journal of Endemiology
Year:
2020
Type:
Article