Effect of alendronate combined with salmon calcitonin in the treatment of elderly patients with hip osteoporotic fracture / 中国基层医药

ABSTRACT

Objective:To investigate the effect of alendronate sodium tablets combined with salmon calcitonin in the treatment of elderly patients with hip osteoporotic fracture, and the changes of serum bone metabolism.Methods:From January 2016 to December 2019, 86 elderly patients with osteoporotic hip fracture who were operated in Xin'an International Hospital were divided into observation group (43 cases) and control group (43 cases) according to the random digital table method.The control group was treated with salmon calcitonin, and the observation group was treated with alendronate sodium on the basis of the control group.The course of treatment was 6 months in both two groups.The changes of serum calcium and phosphorus, Harris score of hip joint and bone metabolism were compared before and after treatment.Results:There were no statistically significant differences in serum calcium and phosphorus levels between the observation group and the control group (all P>0.05). After treatment, the Harris score of hip joint in the observation group[(87.10±3.46)points] was higher than that in the control group [(78.65±4.32)points]( t=10.011, P<0.05). The serum β-CTX [(0.27±0.05)μg/L] in the observation group was lower than that in the control group [(0.39±0.07)μg/L], while the ALP [(117.93±10.15)U/L] in the observation group was higher than that in the control group[(98.32±8.97)U/L], the differences were statistically significant( t=9.147, 9.493, all P<0.05). Conclusion:Alendronate combined with salmon calcitonin can improve the bone metabolism of elderly patients with hip osteoporotic fracture, and improve the function of hip joint.