Thyroid hormones——Seven decades of clinical application / 中华内分泌代谢杂志

ABSTRACT

Synthetic thyroid hormones have been used in the treatment of hypothyroidism for 70 years since the synthesis of thyroxine sodium salt in 1949. There have been accumulated evidences for the facts that levothyroxine sodium (L-T 4) replaces the desiccated thyroid extracts as the mainstay of thyroid hormone preparation, the specifications for L-T 4 preparations change from loose to strict, L-T 4 dosage is increasingly individualized in clinical application, as well as the combined treatment with L-T 4/L-T 3. Based on the review and analysis of the existing literature, our review is tried to summarize the development history of thyroid hormone preparation and its clinical application.