Analysis of risk factors for hypogonadism in male patients with hyperuricemia / 中华内分泌代谢杂志

ABSTRACT

Objective:To explore the risk factors for hypogonadism in male patients with hyperuricemia(HUA).Methods:A total of 245 male patients with HUA were enrolled. Height, weight, waist circumference (WC), blood pressure, serum uric acid(SUA), triglyceride (TG), total cholesterol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, alanine aminotransferase(ALT), aspartate aminotransferase, glutamyltranspeptidase, blood urea nitrogen, serum creatinine, fasting blood glucose (FPG), fasting insulin (FINS)and sex hormones were measured in all patients. And then body mass index (BMI), free testosterone(FT), and homeostasis model assessment of insulin resistance index (HOMA-IR)were calculated. Male androgen deficiency questionnaire (ADAM)and male aging symptom questionnaire (AMS)were conducted. The patients were divided into hypogonadism group ( n=102)and normal gonadal function group ( n=143) according to FT level as well as ADAM and AMS questionnaires. The differences in different metabolic indicators between the two groups and the correlation with hypogonadism were analyzed. Results:Compared with the normal gonadal function group, WC, SUA, BMI, FPG, FINS, HOMA-IR, TG, and ALT were significantly increased, while estradiol level was significantly reduced in the hypogonadism group (all P<0.05). The proportions of nonalcoholic fatty liver, hyperlipidemia, and obesity were significantly increased in the hypogonadism group (all P<0.05). Logistic regression analysis showed that SUA, BMI, WC, HOMA-IR, and TG were independent risk factors for hypogonadism in male HUA patients. Multivariate regression analysis showed that SUA still was a risk factor after adjusting for other factors. Conclusion:Male patients with HUA were often accompanied by hypogonadism. SUA, BMI, WC, HOMA-IR, and TG were risk factors for hypogonadism in male patients with HUA.