Histone methyltransferase EZH2 in the pathogenesis of lymphoma / 中华皮肤科杂志
Chinese Journal of Dermatology
; (12): 71-74, 2020.
Article
in Zh
| WPRIM
| ID: wpr-870225
Responsible library:
WPRO
ABSTRACT
Epigenetic modification is one of the important causes for the occurrence and development of cancers.Enhancer of zeste homolog 2 (EZH2),as an important member of the epigenetic suppressor polycomb group (PcG),can tri-methylate lysine at amino acid position 27 of histone H3 gene,and participates in the regulation of cell cycle,cell aging and cell differentiation.Recently,overexpression or mutation of EZH2 has been detected in a variety of solid tumors and B-cell lymphomas.However,the expression status and action mechanism of EZH2 in some T-cell lymphomas are still unclear,and its action mechanisms in different tumors are not completely consistent,which need further study.
Full text:
1
Index:
WPRIM
Type of study:
Etiology_studies
Language:
Zh
Journal:
Chinese Journal of Dermatology
Year:
2020
Type:
Article