New thoughts on neonatal hypoxic-ischemic encephalopathy in post-cooling era / 中华围产医学杂志

ABSTRACT

Management of the neonatal hypoxic-ischemic encephalopathy (HIE) has been evolving from a pre-cooling era with supportive therapy to standardized cooling era and currently to a post-cooling era over the last two decades. To further decrease the mortality and morbidity of HIE in post-cooling era, we need to focus on the selection of HIE patients who may benefit from cooling and optimization of the available cooling approaches, and to identify research gaps with regard to therapeutic strategies such as combining cooling with promising neuroprotective agents.