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Recent advancement in targeting the KRAS-G12C mutant for cancer therapy / 药学学报
Acta Pharmaceutica Sinica ; (12): 374-382, 2021.
Article in Zh | WPRIM | ID: wpr-873780
Responsible library: WPRO
ABSTRACT
RAS, as a well-known proto-oncogene, is the most frequently mutated oncogene in human cancers, yet tremendous efforts over the past 30 years have failed to develop effective therapies for RAS-mutant cancer. Recently, specifically targeting the KRAS-G12C mutant, a frequently occurring KRAS mutation in human cancers, has shown promise in conquering KRAS-mutant cancers, and has inspired interest in this direction. We herein review the very recent progress achieved in the development of covalent inhibitors towards KRAS-G12C mutant, in combinational therapies and in proteolysis-targeting chimeras (PROTACs)-based approaches to disrupt KRAS-G12C protein. We provide insights for drug discovery against KRAS-G12C-mutated tumors and discuss the potential challenges in this field.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Acta Pharmaceutica Sinica Year: 2021 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Acta Pharmaceutica Sinica Year: 2021 Type: Article