Bcl-2 and Bax Expression and Ki-67 Proliferative Index in Astrocytic Tumors: in Relation to Prognosis
Journal of Korean Neurosurgical Society
; : 465-471, 2004.
Article
in Ko
| WPRIM
| ID: wpr-87700
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: We report a retrospective investigation of the prognostic value of bcl-2 and bax expression, and Ki-67 proliferative index in 42 astrocytic tumors. METHODS: We classified the astrocytic tumors and reviewed the clinical information and survival time. The sections were taken from surgically resected paraffin-embedded tissue and performed immunohistochemical stains for bcl-2, bax and Ki-67. RESULTS: The immunohistochemical stain for bcl-2 revealed a positivity in only two(4.76%) among forty-two cases. The immunostain for bax was positive in 35 cases(83.3%). However, the correlation between bcl-2 & bax expression and age, sex, tumor location, size, and histologic grade was not found. By Kaplan-Meier analysis, bcl-2 & bax expression and survival time in astrocytic tumors was no significance in log rank test(p>0.05). There were prognostic values between Ki-67 LI and histologic grade and between Ki-67 LI and survival time, respectively(p<0.05). CONCLUSION: Bcl-2 and bax are not significant, whereas Ki-67 LI is suggested as a significant prognostic factor, associated with histologic grade and survival time of astrocytic tumors.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
/
Retrospective Studies
/
Coloring Agents
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Kaplan-Meier Estimate
Type of study:
Observational_studies
/
Prognostic_studies
Language:
Ko
Journal:
Journal of Korean Neurosurgical Society
Year:
2004
Type:
Article