Progress of antibiotic-loaded bone cement in joint arthroplasty / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 2486-2494, 2020.
Article
in En
| WPRIM
| ID: wpr-877851
Responsible library:
WPRO
ABSTRACT
Bone cement, consisting of polymethyl methacrylate, is a bioinert material used for prothesis fixation in joint arthroplasty. To treat orthopedic infections, such as periprosthetic joint infection, antibiotic-loaded bone cement (ALBC) was introduced into clinical practice. Recent studies have revealed the limitations of the antibacterial effect of ALBC. Moreover, with the increase in high infection risk patients and highly resistant microbes, more researches and modification of ALBC are required. This paper reviewed latest findings about ALBC for most popular and destructive pathogens, summarized the influence of antibiotic kind, drug dosage, application method, and environment towards characteristic of ALBC. Subsequently, new cement additives and clinical applications of ALBC in joint arthroplasty were also discussed.
Full text:
1
Index:
WPRIM
Main subject:
Bone Cements
/
Prosthesis-Related Infections
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Polymethyl Methacrylate
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Arthroplasty, Replacement, Knee
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Chinese Medical Journal
Year:
2020
Type:
Article