Positive inotropic effect of phosphodiesterase type 9 inhibitor PF-04449613 in rats and its underlying mechanism / 生理学报
Acta Physiologica Sinica
; (6): 275-285, 2021.
Article
in Zh
| WPRIM
| ID: wpr-878256
Responsible library:
WPRO
ABSTRACT
This study aimed to explore the positive inotropic effect of phosphodiesterase type 9 (PDE9) inhibitor PF-04449613 in ratsand its cellular and molecular mechanisms. The heart pressure-volume loop (P-V loop) analysis was used to detect the effects of PF-04449613 on rat left ventricular pressure-volume relationship, aortic pressures and peripheral vessel resistance in healthy rats. The Langendorff perfusion of isolated rat heart was used to explore the effects of PF-04449613 on heart contractility. The cardiomyocyte sarcoplasmic reticulum (SR) Ca
Full text:
1
Index:
WPRIM
Main subject:
Phosphodiesterase Inhibitors
/
Sarcoplasmic Reticulum
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Calcium
/
Phosphoric Diester Hydrolases
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Ryanodine Receptor Calcium Release Channel
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Myocytes, Cardiac
/
Myocardial Contraction
Limits:
Animals
Language:
Zh
Journal:
Acta Physiologica Sinica
Year:
2021
Type:
Article