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Positive inotropic effect of phosphodiesterase type 9 inhibitor PF-04449613 in rats and its underlying mechanism / 生理学报
Acta Physiologica Sinica ; (6): 275-285, 2021.
Article in Chinese | WPRIM | ID: wpr-878256
ABSTRACT
This study aimed to explore the positive inotropic effect of phosphodiesterase type 9 (PDE9) inhibitor PF-04449613 in ratsand its cellular and molecular mechanisms. The heart pressure-volume loop (P-V loop) analysis was used to detect the effects of PF-04449613 on rat left ventricular pressure-volume relationship, aortic pressures and peripheral vessel resistance in healthy rats. The Langendorff perfusion of isolated rat heart was used to explore the effects of PF-04449613 on heart contractility. The cardiomyocyte sarcoplasmic reticulum (SR) Ca
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphodiesterase Inhibitors / Sarcoplasmic Reticulum / Calcium / Phosphoric Diester Hydrolases / Ryanodine Receptor Calcium Release Channel / Myocytes, Cardiac / Myocardial Contraction Limits: Animals Language: Chinese Journal: Acta Physiologica Sinica Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phosphodiesterase Inhibitors / Sarcoplasmic Reticulum / Calcium / Phosphoric Diester Hydrolases / Ryanodine Receptor Calcium Release Channel / Myocytes, Cardiac / Myocardial Contraction Limits: Animals Language: Chinese Journal: Acta Physiologica Sinica Year: 2021 Type: Article