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Effect of / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 356-363, 2021.
Article in English | WPRIM | ID: wpr-878371
ABSTRACT
Objective@#This study aimed to investigate the effects of @*Methods@#In this study, 0.1% DMG was supplemented in 20% casein diets that were either folate-sufficient (20C) or folate-deficient (20CFD). Blood and liver of rats were subjected to assays of Hcy and its metabolites. Hcy and its related metabolite concentrations were determined using a liquid chromatographic system.@*Results@#Folate deprivation significantly increased pHcy concentration in rats fed 20C diet (from 14.19 ± 0.39 μmol/L to 28.49 ± 0.50 μmol/L; @*Conclusion@#DMG supplementation exhibited hypohomocysteinemic effects under folate-sufficient conditions. By contrast, the combination of folate deficiency and DMG supplementation has deleterious effect on pHcy concentration.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sarcosine / Biomarkers / Random Allocation / Chromatography, Liquid / Rats, Wistar / Dietary Supplements / Diet / Folic Acid Deficiency / Homocysteine / Liver Limits: Animals Language: English Journal: Biomedical and Environmental Sciences Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sarcosine / Biomarkers / Random Allocation / Chromatography, Liquid / Rats, Wistar / Dietary Supplements / Diet / Folic Acid Deficiency / Homocysteine / Liver Limits: Animals Language: English Journal: Biomedical and Environmental Sciences Year: 2021 Type: Article