Bile acid detection by biosensors-a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2779-2790, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-878529
ABSTRACT
Bile acids facilitate the absorption of lipids, and affect the development of various diseases by regulating intestinal flora structure and modulating immunity and metabolism. It is therefore important to quantitatively detect bile acids. Current analytical methods are still immature due to constituent complexity, structural heterogeneity and bioactive variability of bile acids. Detection of individual bile acids is of significance for pharmacological research, clinical diagnosis and disease prevention. Advances have been made in bile acid analysis from multiple sources including serum, bile, urine and feces, although several limitations still exist for bile acid quantification. Here we review research progress in conventional bile acid assays, including spectrophotometry, thin-layer chromatography, liquid/gas chromatography and liquid/gas chromatography-mass spectrometry. Moreover, we emphasize the development of bile acid biosensors that may have promising prospects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bile
/
Bile Acids and Salts
/
Biosensing Techniques
/
Chromatography, Thin Layer
/
Gas Chromatography-Mass Spectrometry
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2020
Type:
Article
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