Expression and Prognostic Value of Cripto-1 in Pancreatic Cancer / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 173-179, 2021.
Article
in Zh
| WPRIM
| ID: wpr-878716
Responsible library:
WPRO
ABSTRACT
Objective To investigate the expression of Cripto-1 in pancreatic cancer and to analyze its clinical significance. Methods Cripto-1 expression in normal pancreas,pancreatic cancer and adjacent non-tumor tissues,chronic pancreatitis tissues and other related tissues was evaluated using immunohistochemistry.The association of Cripto-1 expression with the clinicopathological characteristics and the prognostic value of Cripto-1 in patients with pancreatic cancer were analyzed. Results The expression of Cripto-1 was higher in chronic pancreatitis tissues,pancreatic cancer and its metastases than in normal pancreas(P=0.019,P=0.025,and P=0.018,respectively).Cripto-1 overexpression was correlated with poorly differentiated pancreatic cancer.The patients with Cripto-1 upregulation had shorter median survival time(8 months vs.16 months,χ
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pancreatic Neoplasms
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Prognosis
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Biomarkers, Tumor
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Carcinoma, Pancreatic Ductal
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Intercellular Signaling Peptides and Proteins
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GPI-Linked Proteins
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Neoplasm Proteins
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2021
Type:
Article