Wnt5a Plays Controversial Roles in Cancer Progression / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
; (4): 357-365, 2020.
Article
in En
| WPRIM
| ID: wpr-879298
Responsible library:
WPRO
ABSTRACT
Wnt5a is a representative Wnt ligand that regulates multiple cellular functions through the Wnt5a non-classical pathway. Although Wnt5a has been implicated in various pathological conditions, its role in cancer is ambiguous and might involve methyl modifications, distinct mRNA isoforms, as well as different downstream pathways. Therefore, it is an essential factor in cancers' progression (invasion, migration, proliferation, and epithelial-mesenchymal transition), and a potential biomarker for prognosis and treatment.
Full text:
1
Index:
WPRIM
Type of study:
Prognostic_studies
Language:
En
Journal:
Chinese Medical Sciences Journal
Year:
2020
Type:
Article